auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice

نویسندگان

kaveh tabrizian department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran

medicinal plants research center, zabol university of medical sciences, zabol, iran

najmeh sadat yaghoobi department of pharmacology and toxicology, faculty of pharmacy, zabol university of medical sciences, zabol, iran

mehrdad iranshahi biotechnology research center and school of pharmacy, mashhad university of medical sciences, mashhad, iran

چکیده

objective(s): auraptene (7-geranyloxycoumarin) (aur), from citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (ache) and beta-secretase inhibitory effects. scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of alzheimer’s disease (ad). this research aimed to investigate the effect of aur on scopolamine-induced avoidance memory retention deficits in step-through task in mice. materials and methods: the effect of four-day pre-training injections of aur (50, 75, and 100 mg/kg, subcutaneous (sc)) and scopolamine (1 mg/kg, ip), and their co-administration on avoidance memory retention in step-through passive avoidance task, was investigated by measuring the latency to enter to the dark chamber. results:pre-training administration of aur caused significant increase in step-through latency in comparison with control group, 48, 96, and 168 hr after training trial. the findings of this study showed that scopolamine (1 mg/kg, ip, for four consecutive days) impaired passive avoidance memory retention compared to saline-treated animals. step-through passive avoidance task results showed that aur markedly reversed scopolamine-induced avoidance memory retention impairments, 24 and 168 hr after training trial in step-through task. conclusion: results from co-administration of aur and scopolamine showed that aur reversed scopolamine-induced passive avoidance memory retention impairments.

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Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice

Objective(s): Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer’s disease (AD). This research aimed to investigate ...

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Auraptene consolidates memory, reverses scopolamine-disrupted memory in passive avoidance task, and ameliorates retention deficits in mice

OBJECTIVES Auraptene (7-geranyloxycoumarin) (AUR), from Citrus species has shown anti-inflammatory, neuroprotective, and acetylcholinesterase (AChE) and beta-secretase inhibitory effects. Scopolamine is a nonselective muscarinic receptor antagonist which causes short-term memory impairments and is used for inducing animal model of Alzheimer's disease (AD). This research aimed to investigate the...

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عنوان ژورنال:
iranian journal of basic medical sciences

جلد ۱۸، شماره ۱۰، صفحات ۱۰۱۴-۱۰۱۹

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